There is evidence that a large Indian settlement was once located near the site of Delaplaine.An Indian mound and a great pile of chipped flint still remain.

The oldest records in the Greene County court house contain numerous references to the town of De la Plaine. For convenience , the name has come to be written as one word.

The main line of the Iron Mountain railroad passed through Delaplaine before Gainesville secured a railroad. When the county safe was purchased in 1877 , it was shipped from St. Louis to Delaplaine, then hauled to Gainesville. Charlie Stedman says that the roads were so bad that the safe had to be pulled on a sled. Three streams had to be crossed during the journey . County court records show that James R. Jackson was paid $200 for hauling the safe from Delaplaine to Gainesville.

Delaplaine is one of the three incorporated towns in Greene County , the other two being Paragould and Marmaduke . The community surrounding Delaplaine produces the major portion of rice grown in Greene County.