What is now Mississippi County once formed a part of Arkansas County, then of Phillips and next of Crittenden, and was finally erected into a separate county by the Territorial legislature November 1, 1833. It was named for the Mississippi River which forms the entire eastern boundary.

The City of Osceola was the original county seat. The County became a dual seat by Act 81 of 1901. This Act divided Mississippi County into Judicial Districts, the Osceola District and the Chickasawba District. The Blytheville Court House was first erected in 1902. In 1919, the present Blytheville Court House was erected.
 
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Last Edited 04/29/21